P2P Call Guide

How to Win a P2P Call for Chemotherapy / Infusion Therapy Denied by MA Plans

Payer-specific strategy, medical necessity arguments, and the exact phrases to use when Medicare Advantage denies Chemotherapy / Infusion Therapy (CPT 96413, 96415, 96417).

Why MA Plans Denies Chemotherapy / Infusion Therapy

Regimen not first-line per NCCN guidelines

Off-label use without compendia support

Continuation after disease progression not justified

Know Medicare Advantage's Criteria

Medicare Advantage plans must cover all services covered by Original Medicare (CMS NCDs and LCDs) but may require prior auth. Plans use various criteria including InterQual, MCG, and proprietary guidelines.

Key policies to know:

  • Must cover all services covered by Original Medicare
  • Can require prior authorization not required by Original Medicare
  • CMS NCDs and LCDs serve as coverage floor
  • Organization determinations must be issued within 14 days (72 hours for expedited)

Building Your Medical Necessity Argument

Cite specific NCCN guideline category and recommendation level

Document prior treatment lines and responses

Reference tumor molecular markers guiding treatment selection

If off-label, cite peer-reviewed evidence or compendia listing

P2P Call Tips for MA Plans

Cite the relevant CMS NCD or LCD -- MA plans cannot deny what Medicare covers

If the service has a CMS NCD, that trumps the MA plan's internal criteria

Reference CMS regulations on MA coverage obligations

Request expedited determination if clinical urgency exists

Guidelines to Reference

  • NCCN Clinical Practice Guidelines by cancer type
  • CMS Anticancer Chemotherapy NCD

Relevant CPT Codes

CPT 96413CPT 96415CPT 96417

Specialty: Oncology

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The P2P Playbook covers payer-specific approaches for Chemotherapy / Infusion Therapy denied by MA Plans -- plus 15 denial objections with word-for-word responses, what reviewers are actually thinking, and the 60-second prep framework. Written by a medical director who reviewed cases for major payers.

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