P2P Call Guide

How to Win a P2P Call for Genetic / Genomic Testing Denied by Cigna

Payer-specific strategy, medical necessity arguments, and the exact phrases to use when Cigna / Evernorth denies Genetic / Genomic Testing (CPT 81479, 81455, 81432).

Why Cigna Denies Genetic / Genomic Testing

Test not considered medically necessary for this diagnosis

Does not meet hereditary cancer testing criteria

Results will not change treatment plan

Know Cigna / Evernorth's Criteria

Cigna uses their own Coverage Policies and InterQual criteria. Medical directors are generally accessible for P2P review.

Key policies to know:

  • Coverage Policies available on cigna.com/coverage-policies
  • Uses eviCore for specialty benefits management
  • Known for step therapy requirements on specialty drugs
  • Collaborative care approach with emphasis on outcomes data

Building Your Medical Necessity Argument

Document how test results will directly change management

Meet NCCN testing criteria (family history, age, tumor type)

Reference specific actionable mutations being tested

Note FDA-approved companion diagnostics if applicable

P2P Call Tips for Cigna

Reference Cigna Coverage Policy by number

Cigna medical directors tend to be collaborative -- frame it as shared decision-making

Emphasize outcomes data and evidence-based medicine

Be prepared to discuss alternatives and why they were insufficient

Guidelines to Reference

  • NCCN Genetic/Familial High-Risk Assessment Guidelines
  • CMS NCD for Next Generation Sequencing

Relevant CPT Codes

CPT 81479CPT 81455CPT 81432

Specialty: Oncology / Medical Genetics

Want the full strategy?

The P2P Playbook covers payer-specific approaches for Genetic / Genomic Testing denied by Cigna -- plus 15 denial objections with word-for-word responses, what reviewers are actually thinking, and the 60-second prep framework. Written by a medical director who reviewed cases for major payers.

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