P2P Call Guide

How to Win a P2P Call for Genetic / Genomic Testing Denied by UHC

Payer-specific strategy, medical necessity arguments, and the exact phrases to use when UnitedHealthcare denies Genetic / Genomic Testing (CPT 81479, 81455, 81432).

Why UHC Denies Genetic / Genomic Testing

Test not considered medically necessary for this diagnosis

Does not meet hereditary cancer testing criteria

Results will not change treatment plan

Know UnitedHealthcare's Criteria

UHC uses InterQual criteria and their own Clinical UM Guidelines (CG series). Medical directors are typically accessible for P2P within 5 business days.

Key policies to know:

  • Requires eviCore for MSK and advanced imaging prior auth
  • Clinical UM Guidelines (CG series) are publicly available online
  • Prior auth through Optum/UHG portal
  • Known for strict step therapy requirements on biologics

Building Your Medical Necessity Argument

Document how test results will directly change management

Meet NCCN testing criteria (family history, age, tumor type)

Reference specific actionable mutations being tested

Note FDA-approved companion diagnostics if applicable

P2P Call Tips for UHC

Reference UHC's own Clinical UM Guideline number (e.g., CG-SURG-71)

UHC medical directors respond well to InterQual criteria language

Be specific about which InterQual subset applies

Have the CG policy number ready -- shows you've done your homework

Guidelines to Reference

  • NCCN Genetic/Familial High-Risk Assessment Guidelines
  • CMS NCD for Next Generation Sequencing

Relevant CPT Codes

CPT 81479CPT 81455CPT 81432

Specialty: Oncology / Medical Genetics

Want the full strategy?

The P2P Playbook covers payer-specific approaches for Genetic / Genomic Testing denied by UHC -- plus 15 denial objections with word-for-word responses, what reviewers are actually thinking, and the 60-second prep framework. Written by a medical director who reviewed cases for major payers.

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