P2P Call Guide

How to Win a P2P Call for Genetic / Genomic Testing Denied by Aetna

Payer-specific strategy, medical necessity arguments, and the exact phrases to use when Aetna denies Genetic / Genomic Testing (CPT 81479, 81455, 81432).

Why Aetna Denies Genetic / Genomic Testing

Test not considered medically necessary for this diagnosis

Does not meet hereditary cancer testing criteria

Results will not change treatment plan

Know Aetna's Criteria

Aetna uses their own Clinical Policy Bulletins (CPBs) and InterQual criteria. CPBs are publicly available and numbered.

Key policies to know:

  • Clinical Policy Bulletins (CPBs) are publicly available and numbered
  • Uses eviCore for radiology and cardiology prior auth
  • Known for detailed, evidence-based CPBs with specific criteria
  • Precertification list updated annually

Building Your Medical Necessity Argument

Document how test results will directly change management

Meet NCCN testing criteria (family history, age, tumor type)

Reference specific actionable mutations being tested

Note FDA-approved companion diagnostics if applicable

P2P Call Tips for Aetna

Reference the specific CPB number and criteria being met

Aetna CPBs are very detailed -- read them before the call

Address each specific criterion in the CPB during the P2P

Aetna medical directors are typically receptive to guideline-based arguments

Guidelines to Reference

  • NCCN Genetic/Familial High-Risk Assessment Guidelines
  • CMS NCD for Next Generation Sequencing

Relevant CPT Codes

CPT 81479CPT 81455CPT 81432

Specialty: Oncology / Medical Genetics

Want the full strategy?

The P2P Playbook covers payer-specific approaches for Genetic / Genomic Testing denied by Aetna -- plus 15 denial objections with word-for-word responses, what reviewers are actually thinking, and the 60-second prep framework. Written by a medical director who reviewed cases for major payers.

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